Molecular analysis at theNF1 locus in astrocytic brain tumors
نویسندگان
چکیده
منابع مشابه
Molecular genetic analysis of p53 intratumoral heterogeneity in human astrocytic brain tumors.
We investigated genetic heterogeneity of astrocytic gliomas using p53 gene mutations as a marker. Different parts of morphologically heterogeneous astrocytic gliomas were microdissected, and direct DNA sequencing of p53 gene exons 5 through 8 was performed. Thirty-five glioma samples and tumor-adjacent normal-appearing brain tissue from 11 patients were analyzed. Sixteen different p53 gene muta...
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Aim This study will explore the genetic and epigenetic alterations in astrocytomas, and identify the critical molecular signatures and signaling pathways for prognosis assessment by multiplatform comprehensive analysis. Method We performed integration analyses of incorporating DNA methylation, mRNA expression, microRNA expression, and long non-coding RNA (lncRNA) expression in 33 astrocytic t...
متن کاملIdentification of lipids in tissue extracts of astrocytic brain tumors
Prerequisite for accurate resections of human brain tumors is the differentiation between tissue of tumor core and tumor margin. All tumor tissue needs to be removed to avoid tumor relaps and to enhance prognosis, but healthy tissue should not be resected coevally in order to maintain normal brain functions. Therefore, the amount of tumor cells and healthy cells in the margin of the tumor is cr...
متن کاملMetabolic profile of lipid extracts obtained by astrocytic brain tumors
Introduction Astrocytic brain tumors – Gliomas in particular – are the most common brain tumors in adults. These malignant neoplasms are characterized by heterogeneous tissue with no distinct differentiation to healthy tissue because of their infiltrative growth. Therefore, the ratio of tumor cells versus healthy tissue in the tumor margin needs to be determined very precisely when the decision...
متن کاملAnalysis of Exon 19 and 39 of ATM Gene in Brain Tumors; Considering the P53 Accumulation
Many studies have been focused on cytogenetic and molecular genetic defects in brain tumors; therefore the role of ATM as a tumor suppressor gene in these tumors is poorly considered. In this study mutation analysis of exon 19 and 39 of ATM gene and P53 accumulation were investigated by PCR-SSCP, sequencing, and flow cytometry . Four polymorphisms including D1853N, IVS 38-8 T?C, F858L, P872T we...
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ژورنال
عنوان ژورنال: Cancer
سال: 1995
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19950815)76:4<674::aid-cncr2820760421>3.0.co;2-4